Baylor College of Medicine
Department of Molecular Physiology and Biophysics
Houston, Texas 77030

Overview
Baylor College of Medicine, an independent, private, and fully accredited biomedical institution, is located in the heart of the Texas Medical Center, one of the largest medical centers in the world. The Medical Center, adjacent to residential areas, covers more than 500 acres and has forty-one institutes, 10,000 students, and 50,000 employees. Baylor is recognized as a leader in biomedical and basic sciences research and ranks among the nation’s top twelve institutions in federally funded research. There is a high degree of interdisciplinary cooperation, not only among the faculty members in basic science areas but also with clinical investigators in the college and associated institutes in the Texas Medical Center. Ongoing research programs being carried out by productive and widely recognized investigators in both the basic sciences and the clinical faculty, coupled with the favorable faculty-student ratio, permits students to be directly involved in and contribute to significant research projects.

The Community
As the nation’s fourth-largest city with nearly 4 million inhabitants, Houston is a vibrant scientific and industrial center. Extensive and affordable cultural and recreational facilities are available: theaters, a symphony orchestra, opera, art museums, a natural history museum, a planetarium, and a wide range of professional and amateur sports. The Texas Medical Center adjoins Hermann Park, which includes a zoo, a garden center, the Miller Outdoor Theater, the Museum of Natural Science, the Burke-Baker Planetarium, a golf course, tennis courts, jogging tracks, and picnic areas. The metropolitan area includes several large university campuses, the Lyndon B. Johnson NASA Manned Spacecraft Center installation, pubic parks, beaches for fishing and swimming alone the coast.

Programs of study and degree requirements
The Department of Molecular Physiology and Biophysics at Baylor College of Medicine offers a research-oriented program of graduate studies that leads to the Ph.D. degree. This program applies the most current methods of molecular and cell biology, electrophysiology, biophysics, immunology, protein biochemistry, and pharmacology to the study of problems of physiological importance. The department participates in Baylor College of Medicine’s M.D. /Ph.D. Program, whose candidates may earn both the degrees of M.D. and Ph.D.

The departmental faculty members are very interactive with ongoing research in the areas of structure and function of ion channels and transport proteins, signal transduction, synaptic plasticity, cell-cycle control, reactive oxygen species, neuronal morphology, drug and gene delivery, and the development of biosensors for genetic diagnosis. In addition, knockout and transgenic nice are used for a number of different types of whole animal studies, including the study of muscle and cardiovascular function, learning and memory, and cancer.

Facilities & Resources
The department occupies 18,000 square feet of contiguous space with recently constructed laboratories and offices. It contains an array of modem facilities and instrumentation. There are laboratories for electrophysiology (voltage clamping, patch clamping, and planar lipid bilayer), protein biochemistry, immunology, cell culture, recombinant DNA, production of transgenic and genetic knockout mice, automated peptide synthesis and microsequencing, microscopy, and fluorescence spectroscopy. Shared facilities include cold rooms, scintillation and gamma counters, molecular modeling workstations, ultracentrifuges, a P2/P3 facility, radioisotope preparation rooms, machine and electronics shops, and darkrooms. Central computational facilities are housed within the department, and all laboratories are connected to this facility via a local area network that also provides access to the central Baylor Computing Resources and to the Internet. The high level of collaboration among the various departments at Baylor College of Medicine and the other institutions in the Houston scientific community provides access to exceptional facilities. The library of the Texas Medical Center, across the street from Baylor college of Medicine, houses more than 175,000 books, subscribes to more than 3,000 journals, and offers access to more than 400 computer databases. A Learning Resource Center, open to students 24 hours a day, provides additional computer access and a quiet area for study.

Expenses and Aid
Costs for Ph.D. students are normally covered by scholarships awarded by the College. Tuition scholarships are available to all students. Stipends for entering Ph.D. students are $24,000 for the academic year. Health insurance is provided for students; additional financial aid is also available. Requests for information regarding financial aid should be addressed to the Financial Aid Office, Baylor College of Medicine, Houston, Texas 77030. Tuition for the academic year is $9,700. Students pay a one-time matriculation fee of $25, a one-time graduation fee of $140 during the fourth year, and a student fee of $150 for first-year students and $20 for subsequent years. Students on temporary visas also pay an annual international services fee of $75 for an F-1 visa or $100 for a J-1 visa.

How to Apply
Applicants should hold a bachelor’s degree with sound preparation in biology, chemistry, biochemistry, physics, and mathematics. They must submit GRE scores (the General Test and an Advanced Subject Test) that are not more than two years old at the time of application. If applying by mail, applicants should submit a $30 nonrefundable filing fee. There is no fee for application sent to the Graduated School directly over the Internet. The application should be accompanied by a statement of research interest and career goals and be supported by three letters of recommendation and official transcripts from all colleges attended. Applications must be submitted by February 1 for consideration for August admission; early application is greatly encouraged. The school year begins in August and ends in July; it consists of five terms, each eight weeks long.

Who to Contact
Director of Graduate Studies
Department of Molecular Physiology and Biophysics
Baylor College of Medicine
One Baylor Plaza
Houston, Texas 77030
Telephone: 713/798-4700
Fax: 713/798-3475
E-mail: molphys@bcm.tmc.edu

http://www.bcm.tmc.edu/physiology.html

THE FACULTY AND THEIR RESEARCH

Susan L. Hamilton, Ph.D., Interim Chairman.

Julius C. Allen, Professor; Ph.D., Alberta.Cell and molecular biology of vascular smooth-muscle growth and proliferation; regulation of gene and protein expression of Na pump a and b subunits: functional biology of membrane proteins. J. Biol. Chem. 276:46605–11, 2001.

Stanley H. Appel, Professor and Chairman; M.D., Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, Matsukawa N (2000) Hippocampal cholinergic neurostimulating peptides (HCNP). Prog Neurobiol 60: 37-83.

Joseph Bryan, Professor; Ph.D., Pennsylvania. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocrine Rev. 20:101–35, 1999.

Wah Chiu, Alvin Romansky Professor; Ph.D., Berkeley. Electron cryomicroscopy of membrane channels. Proc. Natl. Acad. Sci. USA 99:138–43, 2002; J. Mol. Bio. 314:253–62, 2001; Nature Struct. Biol. 8:868–73, 2001.

Mariella DeBiasi, Assistant Professor; Ph.D., Franceschini, D., Orr-Urtreger, A., Yu, W., Mackey, L. Y., Bond, A. R., Armstrong, D., Patrick, J. W., Beaudet, A. L., and De Biasi, M., (1999). Impaired sympathetic baroreflex responses in mice lacking the a7 subunit of neuronal nicotinic acetylcholine receptors. Under review.

Burton F. Dickey, Associate Professor; M.D., Connecticut. Signal transduction in leukocytes and epithelial cells; control of secretion; structure-function of G-proteins. Am. J. Resp. Cell Mol. Biol. 20:79–89, 1999. J. Biol. Chem. 273:25850–55, 1998;

Henry F. Epstein, Professor; M.D., Stanford. Protein machines and self-assembly in muscle and actin cytoskeleton organization. Science 295:669–71, 2002; BioEssays 21:813–23, 1999; J. Cell Biol. 143:1215–25, 1998; J. Cell Biol. 140:347–53, 1998.

Robert W. Gereau IV, Assistant Professor; Ph.D., Emory. The role of metabotropic glutamate receptors in pain transmission and the structural determinants of receptor function. Proc. Natl. Acad. Sci. U.S.A. 95:8969–70, 1996.

* Susan L. Hamilton, Professor; Ph.D., Colorado. Structure and function of proteins involved in excitation-contraction coupling in skeletal and cardiac muscle. Biophys. J. 77:1936–44; 1999; J. Biol. Chem, 274:36831–4, 1999; Nature 391:489–92, 1998.

Jeffrey Wade Harper, Ph.D., Professor; Ph.D., Georgia Institute of Technology. Protein kinases and ubiquitin ligases in cel lcycle control and signalling. Genes and Development 14, 2298-2313; 2000; Science, 284, 662-65; 1999.

Daniel Johnston, Professor; Ph.D., Duke. Synaptic integration and synaptic plasticity in hippocampus. Proc. Natl. Acad. Sci. (USA), 99: 8366-8371, 2002; J. Neurosci. 22:4860-4868, 2002; Science 297:211-218, 2002; Nature Neurosci. 5:767-774, 2002.

* Eric Klann, Associate Professor; Ph.D., Virginia. Signaling cascades underlying hippocampal synaptic plasticity and memory function. J. Neurosci. 22:674–83, 2002. Director Graduate Studies; Learning modalities of graduate and postdoctoral students.

*Vernon Knight, Distinguished Service Professor; M.D., Harvard. Drug-liposome formulations for aerosol treatment of cancer and of inflammatory, immunological, and infectious lung diseases. Cancer Chemother. Pharmacol. 44:177–86, 1999; Cancer Chemother. Pharmacol. 44:187–92, 1999; J. Gene Medic. 1:251–64, 1999.

* Jeannette Kunz, Assistant Professor; Ph.D. The structure function and regulation of phosphoinositide phosphate kinases. Mol. Cell.
5(1):1–11, 2000.

*Steen E. Pedersen, Associate Professor; Ph.D., Virginia. Structure and function of ligand-gated ion channels investigated by ligand binding, protein biochemistry, and fluorescence spectroscopy. J. Biol. Chem. 276:23589–98, 2001.

Paul J. Pfaffinger, Associate Professor, Ph.D. Structure, function and regulation of ion channels J Biol Chem, 275, 5337-5346, 2000. Nature Struct. Biol. 7: 403-407, 2000. J. Biol. Chem. 276 28493-28502, 2001.

Florante A. Quiocho, Professor; Ph.D., Yale. Structural biophysics and biology; X-ray crystallography of proteins and biological compounds. Cell 85:247–56, 1996; Science 257:1251–5, 1992.

Michael B. Reid, Professor; Ph.D., Texas Southwestern. Physiology of limb and respiratory skeletal muscle; free radical biology; regulation of excitation-contraction coupling; mechanisms of fatigue; control of myocyte gene expression; cachexia; muscle adaptation to space flight. Am. J. Physiol. 278:R95–100, 2000; Am. J. Resp. Crit. Care Med. 160:1205–11, 1999; FASEB J. 12:871–80, 1998;

Robert Roberts, Professor; M.D., Dalhousie. Localization of a gene responsible for arrythmogenic right ventricular dysplasia to chromosome 3p23. Circulation 98:2791–5, 1998.

J. David Sweatt, Professor; Ph.D., Vanderbilt. The NMDA receptor and protein kinases involved in long-term potentiation. J. Biol. Chem. 275:5337–46, 2000.

* Gang-Yi Wu, Assistant Professor; Ph.D., Chinese Academy of Sciences. Cell signaling and synaptic plasticity. Nature Neurosci. 4:499–506, 2001; Science 274:972–6, 1996.

Samuel M. Wu, Professor, Ph.D. Harvard. Membrane biophysics and synaptic transmission, information processing in the retina. J. Neuroscience, 22: 4693-4710, 2002; J. Physiology, 539:239-251, 2002.

* Pumin Zhang, Professor; Ph.D., Wisconsin-Madison. Molecular genetics of cell cycle control, cell cycle control in development and disease. Nature Genet. 30:31–9, 2002; Nature 387:151–8, 1997.

* Primary Appointment is in the Department of Molecular Physiology and Biophysics.

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