Baylor College of Medicine Department of Molecular Physiology and Biophysics Houston, Texas 77030
Overview The graduate students in the Department of Molecular Physiology and Biophysics comprise an eclectic group with varied academic backgrounds, from physics to biology. They are an integral part of the Graduate School of Biomedical Sciences that included 482 Ph.D. students enrolled in 200405. The department also maintains a vigorous postdoctoral training program that includes research fellows and visiting scientists. The Location and Community Programs of study and degree requirements The departmental faculty members are very interactive with ongoing research in the areas of structure and function of ion channels and transport proteins, signal transduction, synaptic plasticity, cell-cycle control, reactive oxygen species, neuronal morphology, drug and gene delivery, development of biosensors for genetic diagnosis, and small-animal in vivo neuronal tract tracing utilizing manganese enhanced magnetic resonance imaging (MEMRI). In addition, knockout and transgenic mice are used for a number of different types of animal studies, including the study of muscle and cardiovascular function, learning and memory, and cancer. Facilities & Resources Expenses and Aid Costs for Ph.D. students are normally covered by scholarships awarded by the College. Tuition scholarships are available to all students. Stipends for entering Ph.D. students are $28,000 for the academic year. Health insurance is provided for students; additional financial aid is also available. Requests for information regarding financial aid should be addressed to the Financial Aid Office, Baylor College of Medicine, Houston, Texas 77030. One residence hall, located adjacent to Baylor College of Medicine in the Texas Medical Center, offers fully furnished rooms and apartments that are moderately priced. There are also a wide range of privately owned furnished and unfurnished apartments and houses available nearby. Housing in Houston is moderately priced compared with other major U.S. cities. How to Apply Who to Contact Telephone: 713-798-5630 Fax: 713-798-3475
E-mail: molphys@bcm.tmc.edu THE FACULTY AND THEIR RESEARCH Wah Chiu, Alvin Romansky Professor; Ph.D., Berkeley. Electron cryomicroscopy of membrane channels (2005), J Mol Biol 345: 427-431; (2005), Structure (Camb). 13:363-372. Mariella DeBiasi, Associate Professor; Ph.D., Padua. The effect of stress on the mechanisms of nicotine addiction. Nicotinic receptors' trafficking and degradation. Nicotine's effects on the proteasome. (2003); Stress Hormone Corticotropin- Releasing Factor Enhances Synaptic NMDA Receptors on Dopamine Neurons. Neuron 39: 387-394. (2004).Decreased signs of nicotine withdrawal in mice null for the b4 nicotinic acetylcholine receptor subunit. J. Neurosci. 24 (5): 10035-10039. * Mary E. Dickinson, Assistant Professor;PhD, Columbia University; 4-Dimensional Cardiac Imaging of Living Embryos via Post-Acquisition Synchronization of Nongated Slice-Sequences. Journal of Biomedical Optics, in press. * Susan L. Hamilton, Professor; Ph.D., Colorado. ; The Skeletal Muscle Ca2+ Release Channel has an Oxidoreductase-like Domain, Proc Natl Acad Sci 99: 12155-60, 2002; A Noncontiguous, Inter-subunit Binding Site for Calmodulin on the Skeletal Muscle Ca2+ Release Channel, J. Biol. Chem. 278:8348 8355, 2003; Dihydropyridine and Ryanodine Receptor Binding After Eccentric Contractions in Mouse Skeletal Muscle, J. Applied Phys. , 96(5):1619-25, 2004; Structure of Ca2+ Release Channel at 14-Å Resolution, J. Molecular Biology, 21;345(3):427-31, 2005; Sites on Calmodulin that Interact with the Carboxyterminal Tail of CaV1.2 Calcium Channel, J. Biol. Chem., 25;208(8):7070-9 2005. * Eric Klann, Associate Professor; Ph.D., Virginia Commonwealth. Molecular mechanisms underlying hippocampal synaptic plasticity and memory function. J. Neurosci. 24: 6352-6361, 2004. * Vernon Knight, Distinguished Service Professor; M.D., Harvard. Drug-liposome formulations for aerosol treatment of cancer and of inflammatory, immunological, and infectious lung diseases. Clinical Cancer Research 10:1-8.,2004: Journal of Aerosol Medicine 17:1(7-14), 2004; Cancer Chemother Pharmacol 54:5 (421-31). * Jeannette Kunz, Assistant Professor; Ph.D., Basel. Structure, function, and regulation of phosphoinositide phosphate kinases in cell polarization and cell motility. Douglas Mann, Professor; M.D., Temple University Medical School. Molecular mechanisms underlying cardiac remodeling and decompenstation. Circulation 2004; 109:262-268. Sean Marrelli, Assistant Professor; Ph.D., Baylor College of Medicine. Role of Endothelial Intermediate Conductance KCa Channels in Cerebral EDHF-Mediated Dilations. Am. J. Physiol. Heart and Circ. Physiol. 2003; 285(4): H1590-9. * Robia G. Pautler, Assistant Professor; Ph.D., Carnegie Mellon. "Mouse MRI: Concepts and Applications in Physiology", Physiology, 2004, 19:168-175. * Steen E. Pedersen, Associate Professor; Ph.D., Virginia. Structure and function of ligand-gated ion channels investigated by ligand binding, protein biochemistry, and fluorescence spectroscopy. J. Biol. Chem. 277:4224958, 2002. Paul J. Pfaffinger, Associate Professor; Ph.D.. Structure, function, and regulation of ion channels. Biophys J. 87(4):2380-96, 2004; Neuron 41(4):573-86, 2004; J Biol Chem. 279(52):54542-51, 2004. Florante A. Quiocho, Professor; Ph.D., Yale. Structural biophysics and biology; X-ray crystallography of proteins and biological compounds. Cell 104:433-40, 2001; Proc. Natl. Acad. Sci. U.S.A. 10:15567-15572, 2004. Michael D. Schneider, The M. D. Anderson Foundation Professor; M.D., U. Pennsylvania. Molecular genetics of cardiac growth and regeneration. Proc. Natl. Acad. Sci. U.S.A. 98:1030813, 2001; Proc Natl Acad Sci U S A.100:5834-9, 2003. Genes Dev. 17:1937-56, 2003. Proc. Natl. Acad. Sci. U.S.A. 100:12313-8, 2003; EMBO J. 23:3559-69, 2004; Mol Cell Biol. 25:2486-97, 2005. Robert Schwartz, Professor; Ph.D., Pennsylvania. Regulation of muscle gene expression; cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth- muscle differentiation cofactors. Dev. Cell 4:10718, 2003. J. David Sweatt, Professor; Ph.D., Vanderbilt. Protein kinases involved in long-term potentiation and memory. J. Neurosci. 23:263444, 2003. Lubov Timchenko,. Associate Professor; Ph.D., Molecular mechanisms of Myotonic Dystrophies I and II. The role of untranslated RNAs and RNA-binding proteins in muscle differentiation. J Biol Chem. 279: 13129-13139, 2004; Mol Cell Biol 21:6927-6938, 2001; J Biol Chem 276:7820-7826, 2001; Am J Hum Gen 64:360- 364, 1999; Hum Mol Genet 8:53-60, 1999; Proc Natl Acad Sci (USA) 94:13221- 13226, 1997. * Gang-Yi Wu, Assistant Professor; Ph.D., Chinese Academy of Sciences. Cell signaling and synaptic plasticity. Nature Neurosci. 4:499506, 2001; Science 274:9726, 1996. Samuel M. Wu, Professor, Ph.D., Harvard. Membrane biophysics and synaptic transmission, information processing in the retina. Neuron, 43,6,779-793, 2004; J. Physiology, 564.3, 849-862, 2005. * Pumin Zhang, Assistant Professor; Ph.D., Wisconsin-Madison. Molecular genetics of cell cycle control, cell cycle control in development and disease. Nature Genet. 30:319, 2002; Nature 387:1518, 1997. *Primary Appointment is in the Department of Molecular Physiology and Biophysics. |