Loyola University Chicago Biochemistry Maywood, Illinois
Overview There are approximately 140 graduate students and 530 medical students at the Medical Center. The Division of Molecular and Cellular Biochemistry has about 17 graduate students from several states and countries; about half are women. There are also doctoral programs in anatomy, microbiology, molecular biology, neuroscience, pharmacology, and physiology at Loyola University Medical Center. Most immediate graduates obtain postdoctoral positions at nationally ranked institutions such as Harvard, Stanford, and Northwestern Universities; the NIH; Mayo Clinic; and others. Some students pursue traineeships in industry. Scientists graduating within the past fifteen years are pursuing careers as teaching-research faculty members at universities, research scientists in industry, or full-time college teachers. Graduates have begun their own technical companies or have obtained further professional training in medicine or law and are utilizing their scientific training as physicians or lawyers. The Location and Community Programs of Study and Degree Requirements Each student works closely with a faculty mentor during the research training. Ph.D. candidates must pass a comprehensive qualifying exam that includes both a written test of critical thinking and problem solving skills as well as the preparation and review of a grant related to the proposed dissertation research. Most students complete the program in 4½ to 5 years. Master's students take a year of concentrated course work, then participate in a one-year focused research project that culminates in a departmental seminar and written thesis report. Students in the seven biomedical doctoral programs at Loyola University Chicago must take a common curriculum during the first semester. This includes courses in the areas of molecular biochemistry, cell biology, systems biology, and methods. After the first semester, students in the Graduate Program in Molecular and Cellular Biochemistry need to take additional courses in molecular biology, cellular biochemistry, structure and function of proteins, and biostatistics. Electives include neurochemistry, advanced eukaryotic genetics, molecular oncology, signal transduction, and cellular and molecular neurobiology. Additional elective courses are available. Major research is being conducted in the biochemistry of apoptosis and transcription factors, second messenger signaling systems, biochemistry of neurodegeneration (especially Parkinson's disease and AIDS), brain development, neurochemical mechanisms of fetal and adult alcohol toxicity, intracellular protein degradation, molecular biology of cancer and metastasis, cell-membrane biochemistry and cell-cell interactions, heat shock proteins, the biosynthesis and action of hormones, gene regulation, and inflammation. Facilities & Resources Expenses and Aid Financial Aid: Housing/Living Expenses: How to Apply To assure consideration for financial aid, applicants are encouraged to complete their applications no later than February 15. The academic year begins in the fall semester, which starts approximately August 1. Who to Contact 708-216-3360 E-mail: egrzeda@lumc.edu The Faculty • Divaker Choubey, Assistant Professor; Ph.D., Indian Institute of Science, 1985. Molecular mechanisms of the regulation of cell proliferation and apoptosis. • Michael A. Collins, Professor; Ph.D., Purdue, 1968. Neurochemistry; biochemical neurotoxicology of alcoholism; endogenous neurotoxins in Parkinsonism; metabolism of carboline alkaloids. • Mitchell F. Denning, Assistant Professor; Ph.D., Wisconsin-Madison, 1991. Signal transduction pathways that regulate normal skin homeostasis; skin carcinogenesis. • Manuel O. Diaz, Professor; M.D., Uruguay, 1976. Expression of gene promoters and transcription factors in T-cell-senescence; role of telomerase and telomeric proteins in regulation of telomere length. • Luisa DiPietro, Associate Professor; D.D.S., Ph.D., Illinois. Inflammation and angiogenesis in tissue repair. • Lydia DonCarlos, Professor; Ph.D., Kent State, 1985. Sexual differentiation of the brain; effects of gonadal steroid hormones on neural development and brain responses to injury. • Mary Ann Emanuele, Professor; M.D., Loyola Chicago, 1975. Effects of ethanol on rat hypothalamic, pituitary, and gonadal gene transcription and translation. • Allen Frankfater, Professor; Ph.D., Duke, 1968. Lysosomal proteinases, the regulation of their expression in metastatic tumors, and role in cancer cell invasion; role of the IGF-II receptor in lysosomal enzyme trafficking and tumor growth. • Hua Huang, Assistant Professor; M.D., China, 1984; Ph.D., Madison-Wisonsin, 1993. Cytokine signaling; helper T-cell differentiation; animal model of asthma. • Jeffrey R. Kanofsky, Professor; Ph.D., IIT, 1972; M.D., Rush, 1975. Biochemistry of oxygen radicals and singlet oxygen. • Elizabeth J. Kovacs, Associate Professor; Ph.D., Vermont, 1984. Mechanisms by which age, gender, and alcohol exposure affect inflammation and cell-mediated immunity after injury. • Ruben Mestril, Assistant Professor; Ph.D., Miami (Florida), 1986. Role of heat shock protein expression in cardiac and myogenic cells during ischemic stress. • Gregory A. Mignery, Associate Professor; Ph.D., Texas A&M, 1987. Structural and functional characterization of the inositol 1,4,5-trisphosphate receptor protein family in cerebellar and cardiac cells; regulation and role of proteins that govern intracellular calcium signaling dynamics. • Erika Piedras-Renteria, Assistant Professor; Ph.D., Illinois, 1996. Molecular mechanisms of neuronal calcium function in normal and pathological conditions. • Richard M. Schultz, Professor; Ph.D., Brandeis, 1969. Mechanism of cancer-cell metastasis and the involvement of proteolytic enzymes in the metastatic process; oncogene pathways in induction of metastasis. • George J. Siegel, Professor; M.D., Miami, 1961. Expression and regulation of Na, K-ATPase in developing and aging brain, retina, and kidney; growth-factor effects in the nervous system; neurodegeneration and therapy of Alzheimer's disease. • William H. Simmons, Professor; Ph.D., Illinois at Chicago, 1979. Mechanisms of vasoactive peptide metabolism; purification and characterization of peptidases; aminopeptidase P inhibitors as cardiovascular drugs. • Evan Stubbs, Assistant Professor; Ph.D., Missouri, 1987. Immune-mediated mechanisms of peripheral neuropathies. • Pamela Witte, Professor; Ph.D., Texas, 1984. B-lymphocytes; stromal cells; hematopoiesis; differentiation; aging. • Nancy Zeleznik-Le, Assistant Professor; Ph.D., Duke, 1988. Characterization of the differences in function of the MLL chimeric fusion protein with the wild type MLL protein in both in vitro and in vivo models of MLL-CBP leukemia. |